Table 3.

Some iron chelators and related compounds under development with potential in AD

Agent	Mechanism of action
M30	MAO-I + IC
2-Amido-3-hydroxypyridin-4-one compounds	IC
Hydroxylated chalcones	Anti-Aβ aggregation + anti-ferroptotic
HLA20A	ACh-I + IC
Tacrine-(hydroxybenzoyl-pyridone) hybrids	ACh-I + IC
Tacrine-deferiprone	ACh-I + IC
Dihydropyrimidinone-derived selenoesters	ACh-I + IC + anti-oxidant
Quinazoline-pyrido-benzorufan-based compounds	ACh-I + IC
3,4-HP-based compounds	Anti-Aβ aggregation + ACh-I + IC
Benzothiazone-based compounds	Anti-Aβ aggregation + ACh-I + IC
Coumarin-quinoline hybrids	ACh-I + IC
1-Phenyl-3-hydroxyl-4-pyridinone derivatives	Anti-Aβ aggregation + IC + anti-oxidant
CuII(atsm)	Anti-ferroptotic
PBPT	ACh-I + CI

MAO-I = monoamine oxidase inhibitor; IC = iron chelator; ACh-I = acetylcholinesterase inhibitor