Table 2.

2-way ANOVA analysis in Eu and Ts2 mice treated with Veh and TMG

2-way ANOVA analysis
Target of interest	Genotype (Eu vs Ts2)	Treatment (Veh vs TMG)	Interaction
O-GlcNAc	F (1,21) = 2.055 p = 0.1665	F (1,21) = 21.25 ***p = 0.0002	F (1,21) = 1.327 p = 0.2622
OGA activity/OGA	F (1,17) = 0.0001521 p = 0.9903	F (1,17) = 3.468 p = 0.0799	F (1,17) = 0.1305 p = 0.7224
OGT	F (1,19) = 0.3515 p = 0.5602	F (1,19) = 0.3289 p = 0.5730	F (1,19) = 0.8781 p = 0.3605
OGA	F (1,22) = 3.710 *p = 0.0498	F (1,22) = 16.83 ***p = 0.0005	F (1,22) = 0.4029 p = 0.5321
OGT mRNA	F (1,20) = 0.9879 p = 0.3321	F (1,20) = 1.047 p = 0.3184	F (1,20) = 1.427 p = 0.2462
OGA mRNA	F (1,20) = 5.337 *p = 0.0317	F (1,20) = 0.02546 p = 0.8748	F (1,20) = 1.985 p = 0.1742
AT8/tau	F (1,19) = 4.441 *p = 0.0486	F (1,19) = 0.08656 p = 0.7718	F (1,19) = 1.069 p = 0.3141
pSer404/tau	F (1,21) = 0.1369 p = 0.7150	F (1,21) = 1.131 p = 0.2997	F (1,21) = 7.610 *p = 0.0118
β-CTF/α-CTF	F (1,17) = 24.06 ***p = 0.0001	F (1,17) = 9.043 **p = 0.0079	F (1,17) = 0.001069 p = 0.9743
Aβ 42	F (1,20) = 0.6361 p = 0.4345	F (1,20) = 8.009 *p = 0.0103	F (1,20) = 0.01148 p = 9157
PSD95	F (1,18) = 0.08181 p = 0.7781	F (1,18) = 7.727 *p = 0.0124	F (1,18) = 0.0691 p = 0.7956
Syntaxin 1A	F (1,18) = 2.324 p = 0.1448	F (1,18) = 16.26 ***p = 0.0008	F (1,18) = 1.398 p = 0.2524
BDNF	F (1,19) = 1.115 p = 0.3043	F (1,19) = 14.05 **p = 0.0014	F (1,19) = 23.08 ***p = 0.0001
Atg7	F (1,21) = 0.05321 p = 0.8198	F (1,21) = 14.48 **p = 0.0010	F (1,21) = 0.1.574 p = 0.2234
Beclin-1	F (1,23) = 0.005176 p = 0.9433	F (1,23) = 16.48 ***p = 0.0005	F (1,23) = 2.745 p = 0.1111
LC3-II/I	F (1,21) = 7.926 *p = 0.0104	F (1,21) = 5.861 *p = 0.0246	F (1,21) = 13.85 **p = 0.0013
SQSTM1	F (1,23) = 2.521 p = 0.1260	F (1,23) = 0.9074 p = 0.3507	F (1,23) = 6.288 *p = 0.0197
3-NT	F (1,21) = 2.401 p = 0.1362	F (1,21) =1.65 p = 0.2130	F (1,21) = 5.68 *p = 0.0180
HNE adducts	F (1,22) = 18.75 ***p = 0.0003	F (1,22) = 2.289 p = 0.1445	F (1,22) = 0.09204 p = 0.7644

Significant p-values are reported in italics