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Timeline diagram of the experimental procedure used for the development of an animal model of spontaneous cocaine withdrawal syndrome. Cocaine administration (15 mg/kg/day–60 mg/kg/day, i.p.) was performed during 12 consecutive days. Six hours after last cocaine dose, the effects of CBD (10, 20 and 40 mg/kg, i.p.) on spontaneous cocaine withdrawal syndrome were evaluated by the open-field and light-dark box paradigms
