Fig. 2.

Evaluation of CBD (10, 20 and 40 mg/kg) effects on motor activity and somatic signs alterations induced by the spontaneous cocaine withdrawal model, in the open-field paradigm. Columns represent the means and vertical lines ± SEM of the total distance recorded (cm) (A) and the number of rearings (B), rubbings (C), groomings (D) and diggings (E). *, values from COCA-VEH-treated group that are significantly different from VEH-VEH controls (one-way ANOVA, P < 0.05). #, values from COCA-CBD-treated groups that are significantly different from COCA-VEH-treated group (one-way ANOVA, P < 0.05). &, values from COCA-CBD (20 and 40 mg/kg)-treated groups that are significantly different from COCA-CBD 10 mg/kg treated group (one-way ANOVA, P < 0.05). Number of mice per group n = 9–10