Table 2.

Intraperitoneal injections of XAV-939, LGK-974, and iCRT14 in rats

Name	Vehicle	Purpose	Dose and schedule
XAV-939	3% DMSO in 1% sodium carboxymethyl-cellulose (CMC) in PBS	Single analgesic effects	0.3, 1, and 3 mg/kg on day 16
		Extended analgesic effects	3 mg/kg twice daily on days 16–19
		Preventive effects	3 mg/kg twice daily on days 6–14
LGK-974	1% DMSO in 1% CMC in PBS	Single analgesic effects	0.5 and 2 mg/kg on day 16
		Extended analgesic effects	2 mg/kg twice daily on days 16–19
		Preventive effects	2 mg/kg twice daily on days 6–14
iCRT14	10% DMSO in 1% CMC in PBS	Single analgesic effects	10 and 30 mg/kg on day 16