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(a) Schematic diagram of the experimental design. The integrity of the blood-brain barrier (BBB) in the cerebral cortex (b) and hippocampus (c) was obtained several times at 12, 18, and 24 h after meningitis induction. Results show the mean ± SEM of animals (n = 6) in each group determined by 2-way ANOVA and Tukey’s test. *p < 0.05 indicates statistical significance compared to the control group; #p < 0.05 indicates statistical significance when compared to the meningitis group
