Table 1.

Key considerations in addressing clinical sleep pathology common in neurodegenerative conditions

Pathology	Example of associated neurodegenerative condition	Key treatment strategies
Obstructive sleep apnea (OSA)	1. Alzheimer’s disease 2. Vascular dementia	1. Continuous positive airway pressure (CPAP) 2. Mandibular devices 3. Positioning techniques
Restless leg syndrome (RLS)	1. Parkinson’s disease	1. Exclude iron/B12 deficiency 2. Consider contribution of antihistamines/antidepressants/ antipsychotics 3. Dopamine agonists, gabapentin, pregabalin 4. Opiates
Periodic limb movement disorder (PLMD)	1. Huntington’s disease [51]	1. Consider contribution of antidepressants/antipsychotics 2. Dopamine agonists
REM behavior sleep disorder (RBD)	1. Parkinson’s disease 2. Lewy body dementia 3. Multiple system atrophy	1. Consider contribution of antidepressants, beta blockers, opioids, clonidine 2. Melatonin [57–59] 3. Clonazepam (except in presence of cognitive impairment/OSA)