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. 2020 Nov 16;18(1):412–429. doi: 10.1007/s13311-020-00958-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Anti-HuR ASO treatment inhibition of BBB permeability in the brain and spinal cord of EAE mice. Representative pictures of liver, kidney, spleen (a), brain, and spinal cords (b) from naïve, CTRL, EAE, and anti-HuR ASO-treated EAE mice are displayed. Blue color indicates extravasated Evans blue dye from blood vessels. The amount of extravasated Evans blue dye was quantified in the brain (c) and lumbar spinal cord (d), at 30 days after immunization (n = 7 per group). A significant increase of extravasated Evans blue dye was detected in the brain and spinal cord of EAE that was attenuated by anti-HuR ASO. CTRL, dODN-treated nonimmunized mice; EAE, dODN-treated EAE mice; EAE + ASO, anti-HuR ASO-treated EAE mice. Error bars represent the standard error of the mean. *p < 0.05, **p < 0.01 versus CTRL; °p < 0.05, °°p < 0.01 versus EAE (ANOVA)