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Mechanism of immune competence, tolerance, and immunopathology toward SARS-CoV-2 infection in different hosts and clinical scenarios. ADE, antibody-dependent enhancement; CNI, calcineurin inhibitors; CTL, cytotoxic T cell; CD71+ EC, CD71+ erythroid precursors; EC, lung epithelial cell; KD, Kawasaki disease; MDSC, myeloid-derived suppressor cells; Mϕ, macrophage; MIS-C, Multisystem Inflammatory Syndrome in Children; PRR, Pattern Recognition Receptor; TLR, Toll-like receptors.
