Figure 5.

Fusogenic findings in in vivo tumor tissues

(A) Schedule of the tumor tissue collection for IHC. Mice bearing bilateral CT26 tumors were treated with 5 × 10⁷ PFUs of MDRVV- or FUVAC-LG/DsRed on days 0, 2, and 4, then tumors were collected on day 5. (B) Bioluminescence imaging before tumor collection on day 5. (C) Whole pictures of virus-treated or -untreated tumors. Upper images show the hematoxylin and eosin staining, and lower images show the anti-GFP antibody staining. Scale bar, 1,000 μm. (D) High-power images of the area marked in (C). Arrows show the fusogenic phenotype. Representative images are shown in (C) and (D). Pictures from the other two mice are shown in Figure S3. Scale bar, 50 μm.