Figure 8.

Effect of PD-1 blockade under FUVAC treatment

(A) Schedule of the combination of virus with PD-1 blockade. (B and C) Tumor growths in mice treated with PBS, MDRVV, or FUVAC + mock (B) or + anti-PD-1 antibodies (C). Data are presented as the mean tumor volume (mm³) ± SEM (n = 5–6). ∗∗∗p < 0.001 (two-way ANOVA). (D) Survival curves of mice associated with (B) and (C) generated using Kaplan-Meier analysis. FUVAC alone prolonged the survival of mice compared with the PBS treatment (∗p = 0.0112). FUVAC + anti-PD-1 prolonged the survival longer than anti-PD-1 antibody alone or MDRVV + anti-PD-1 (∗∗∗p = 0.0007 or ∗∗p = 0.0066, respectively, using log-rank test). (E) Tumor growths in CR mice and control mice after tumor rechallenge (n = 3).