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. 2021 Jan 21;29(5):1794–1807. doi: 10.1016/j.ymthe.2021.01.021

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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The CD39⁺ HBVs-CAR-T cells exerted an enhanced effector function and a downregulation of inhibitory receptors

(A) Representative flow cytometry plots of CD107a and IFN-γ gated on CD39^+/− HBVs-CAR-T cells after being co-cultured with autologous tumor organoids. GP120-CAR-T cells served as NC. (B and C) Relative quantification of IFN-γ and CD107a expression of CD39^+/− CAR-T cells. Error bars represent SEMs of 3 biological replicates. (D) Flow cytometry analysis of inhibitory receptor expression of CD39^+/− HBVs-CAR T cells.