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. 2021 Apr 29;15:621477. doi: 10.3389/fnins.2021.621477

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Copyright © 2021 Zhu, Zhu, Hou, Chen, Qu, Zhang, Li, Wang, Chen, Lv, Wang, Zhang and Hou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Relative Citrullinated histone H3 (CitH3) protein expression level in the PVN of the control group and each experimental subgroup (*P < 0.05 and ***P < 0.001). (B) CitH3 protein expression in the PVN of the control group and each experimental subgroup were detected by WB. (C) Relative level of metanephrine was positive correlate to that of CitH3 (NETs) according to Pearson correlational analysis, r = 0.879, P < 0.001. (D) Relative level of normetanephrine was positive correlate to that of CitH3 (NETs) according to Pearson correlational analysis, r = 0.683, P = 0.002. Grouping: DAI group (n = 18) and sham-injury group (n = 18).