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. 2021 Apr 29;15:595583. doi: 10.3389/fnins.2021.595583

FIGURE 10.

FIGURE 10

Beta diversity of bacteria in fecal samples collected from non-transgenic (NoTg) and Alzheimer’s disease triple-transgenic (3xTg-AD) mice. The graphics show beta diversity analyses calculated by dissimilarity metrics using operational taxonomic unit (OTU) tables and Unweighted UniFrac analyses. The analyses show the dissimilarity among mice by colors: NoTg female at 3 months (m) old (cyan), 3xTg-AD female at 3 months old (black), NoTg female at 5 months old (pink), 3xTg-AD female at 5 months old (green), NoTg male at 3 months old (purple), 3xTg-AD male at 3 months old (red), NoTg male at 5 months old (yellow), 3xTg-AD male at 3 months old (blue). The data is comparing by sex NoTg and 3xTg; NoTg female and male mice at 3 months (A), NoTg female and male mice at 5 months (B), 3xTg female and male mice at 3 months (C), and 3xTg female and male mice at 5 months (D). The three-dimensional scatter plots were generated using principal coordinates analyses (PCoA) in three different axes which shows the percentage of total differences. There is significant difference on (A) according to ANOSIM similarity test (R = 0.225, p = 0.002), but no for (B, R = 0.082, p = 0.102), (C, R = 0.037, p = 0.231), and (D, R = 0.029, p = 0.275).