FIGURE 11.

Bacteria with a statistically significant change between non-transgenic (NoTg) and Alzheimer’s disease triple-transgenic (3xTg-AD) mice at 3 and 5 months (m) old in male and female in fecal samples. The bacteria with statistical relevance are shown by colors: red color indicates 3xTg-AD male at 3 months old; green, 3xTg-AD female at 3 months old; blue, 3xTg-AD female at 5 months old; pink, NoTg male at 3 months old; cyan, NoTg female at 3 months old; light olive, NoTg female at 5 months old. Horizontal bars represent the effect size for each taxon. The length of the bars represents the log₁₀ transformed linear discriminant analysis (LDA) score, indicated by vertical dotted lines. The threshold on the logarithmic LDA score for discriminative features was set to 2.0. The name of bacteria with a statistically significant change in the relative abundance is written alongside the horizontal lines. Taxa names are abbreviated as “o,” order; “f,” family, and “g,” genus. See Supplementary Table 5 for full taxon description and LDA score and p values.