Table 2.

Adjusted odds ratios for confirmed cases of covid-19 by interval after vaccination with the Pfizer-BioNTech BNT162b2 vaccine before 4 January 2021 in those aged 80 years and older

	No of controls	No of cases	Odds ratio* (95% CI)	Adjusted odds ratio† (95% CI)	Odds ratio v post-dose days 4-9† (95% CI)
Unvaccinated	15 718	8988	Base	Base
First dose
Interval after dose (days):
0-3	277	167	1.17 (0.96 to 1.42)	1.22 (1.00 to 1.48)
4-6	241	179	1.26 (1.03 to 1.54)	1.28 (1.05 to 1.56)
7-9	252	257	1.47 (1.23 to 1.76)	1.48 (1.23 to 1.77)
10-13	361	284	1.12 (0.95 to 1.31)	1.13 (0.96 to 1.33)	0.82 (0.67 to 1.01)
14-20	462	336	1.03 (0.89 to 1.19)	1.06 (0.92 to 1.23)	0.77 (0.63 to 0.94)
21-27	288	118	0.60 (0.48 to 0.75)	0.64 (0.51 to 0.79)	0.46 (0.35 to 0.60)
28-34	290	72	0.40 (0.30 to 0.52)	0.41 (0.32 to 0.54)	0.30 (0.22 to 0.41)
35-41	274	65	0.45 (0.34 to 0.60)	0.49 (0.37 to 0.66)	0.36 (0.26 to 0.49)
≥42	396	59	0.34 (0.25 to 0.47)	0.39 (0.29 to 0.55)	0.28 (0.20 to 0.40)
Second dose
Interval after dose (days):
0-3	116	45	0.55 (0.39 to 0.77)	0.59 (0.41 to 0.83)	0.42 (0.29 to 0.62)
4-6	80	30	0.52 (0.34 to 0.80)	0.57 (0.37 to 0.88)	0.41 (0.26 to 0.65)
7-13	201	28	0.20 (0.13 to 0.29)	0.21 (0.14 to 0.32)	0.15 (0.10 to 0.23)
≥14	634	41	0.13 (0.09 to 0.18)	0.15 (0.11 to 0.21)	0.11 (0.07 to 0.15)

^*Odds ratio period adjusted by week of onset.

^†Adjusted for age, period, sex, region, ethnicity, care home, and index of multiple deprivation fifth.