Table 1.
Antiviral activity of the target compounds against influenza A virus PR8 (H1N1) in MDCK cells
| Compound | CC50a (µM) | IC50b (μM) | SIc |
|---|---|---|---|
| 1* | >2252 | 52.7 ± 0.4 | 43 |
| 2* | >2118 | 21.2 ± 0.1 | 100 |
| 6 | >2101 | 115 ± 10 | 18 |
| 7 | >1992 | 144 ± 12 | 14 |
| 8a | 597 ± 42 | 163 ± 21 | 4 |
| 8b | >1184 | NA | - |
| 8c | >1122 | 97 ± 10 | 12 |
| 9a | 79 ± 6 | >41 | 2 |
| 9b | 814 ± 65 | 36 ± 5 | 23 |
| 9c | 34 ± 2 | >14 | 3 |
| 10a | 1311 ± 126 | 2.4 ± 0.4 | 546 |
| 10c | 264 ± 15 | >117 | 2 |
| 11a | 850 ± 38 | 316 ± 40 | 3 |
| 11b | 69 ± 6 | >37 | 2 |
| Rimantadine | 335 ± 27 | 67.0 ± 4.9 | 5 |
| Amantadine | 284 ± 21 | 64.2 ± 4.7 | 4 |
| Deitiforine | 1266 ± 81 | 209 ± 15 | 6 |
| Ribavirin | >2000 | 24.6 | >81 |
The data presented are the mean value of three independent experiments. The values for CC50 and IC50 are presented as the mean ± error of the experiment
NA not active
*Data published previously [11]
aCC50 is the cytotoxic concentration, i.e., the concentration resulting in the death of 50% of the cells
bIC50 is 50% virus-inhibiting concentration, i.e., the concentration leading to 50% inhibition of virus replication
cSI is the selectivity index, i.e., the ratio of CC50/IC50