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. 2021 May 13;44(2):1047–1069. doi: 10.1007/s11357-021-00375-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Graphical abstract. Aged male and female control rats display sex differences in the brain. PRS induces brain demasculinization, thereby abolishing sex differences. PRS does not affect females as much as males during aging, suggesting that females are protected against PRS. Males are represented in blue, and females are represented in pink. E = embryologic day; P = postnatal day