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. 2021 Apr 29;9:629212. doi: 10.3389/fcell.2021.629212

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Copyright © 2021 Szlachcic, Ziojla, Kizewska, Kempa and Borowiak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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sc-RNA-Seq insight into murine pancreatic development. (A) Three major morphogenesis transitions in pancreatic development are shown. Cell types with cell specific markers are listed in the legend below. The black arrow indicates the developmental trajectory. MP, multipotent progenitors; BP, bipotent progenitors; EP, endocrine progenitors. (B) Developmental trajectory of Pro-EP trunk and EP cells as they differentiate at e13.5–e14.5 preferably into α-cells, and at e15.5–e16.5 preferably into β-cells. Time point-specific markers are listed above the scheme.