Graphical annotation and comparative alignment of pKP15.12_OXA-181. The resistance genes (light green-coloured arrows), transporter genes (deep green-coloured arrows), methyltransferases/restriction endonucleases (rose-coloured arrows), transposons (orange-coloured arrows), insertion sequences (orange-coloured arrows), integrons (red-coloured arrows), resolvases (red-coloured arrows) and recombinases/integrases (red-coloured arrows) on the plasmid are shown with their orientation (direction of arrow), synteny and immediate environment. Other genes with unknown functions are hidden to make the image less cluttered. A circular version of the plasmid is shown in (a). A linear version of the plasmid and its alignment with other similar plasmids (linear arrows with yellow highlighted background) are shown in (b); regions of alignment are shown as red-filled portions whilst non-aligned areas are shown as empty arrows. An enlarged section of the plasmid focusing on the resistance genes (genomic resistance island) is shown in (c). This plasmid (VXIZ01000012) contains OXA-181.