Table 3.
Comparison of clinical and biologic characteristics between COL4A3-cIgAN and non‒COL4A-cIgAN RKB patients at onset and last follow-up (before kidney transplantation)
| COL4A3-cIgAN (4) | Non‒COL4A3-cIgAN RKB (5) | P value | |
|---|---|---|---|
| Variables at onset | |||
| Age (years) | 9 (6.5‒13) | 11.10 (8.669‒15.12) | |
| Familial IgAN history | 2 (50%) | 0 (0%) | |
| Female | 3 (75%) | 3 (60%) | |
| eGFR (ml/min per 1.73 m2) | 67.21 (31.26–114.2) | 1131 (63.88–113.8) | 0.3772 |
| Serum albumin (g/L) | 28.5 (18.33–34.48) | 30 (26–44.1) | 0.5556 |
| Proteinuria (g/mmol) | 0.52 (0.1163–1.339) | 0.1074 (0.049–0.1935) | 0.1905 |
| Pathologic findings | |||
| M1 | 4; 100% (n = 4) | 3; 60% (n = 5) | |
| E1 | 3; 75% (n = 4) | 5; 100% (n = 5) | |
| C1 | 3; 75% (n = 4) | 4; 80% (n = 5) | |
| S1 | 2; 50% (n = 4) | 4; 80% (n = 5) | |
| T1 | 0; 0% (n = 4) | 2; 40% (n = 5) | |
| Variables at last follow-up | |||
| eGFR (ml/min per 1.73 m2) | 90 (57–117.5) | 77 (30–85) | 0.3091 |
| Serum albumin (g/L) | 42.45 (37.35–47.93) | 32.3 (30.50–39.10) | 0.0635 |
| Proteinuria (g/mmol) | 0.041 (0.0062–0.936) | 0.2 (0.1333–0.25) | 0.3810 |
| Pathologic findings | |||
| M1 | 0; 0% (n = 3) | 4; 80% (n = 5) | |
| E1 | 0; 0% (n = 3) | 5; 100% (n = 5) | |
| C1 | 1; 33% (n = 3) | 1; 20% (n = 5) | |
| S1 | 3; 100% (n = 3) | 3; 60% (n = 5) | |
| T1 | 0; 0% (n = 4) | 2; 40% (n = 5) |
C1, extracapillary proliferation; cIgAN, childhood IgA nephropathy; COL4A3/4, collagen type 4 alpha 3/4; E1, endocapillary hypercellularity; eGFR, estimated glomerular filtration rate; M1, mesangial hypercellularity; RKB, repeat kidney biopsy; S1, segmental glomerulosclerosis or adhesion; T1, tubular atrophy/interstitial fibrosis.
For quantitative variables, values are expressed as median (interquartile range). For qualitative variables, values are expressed as number (%).