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. 2021 Apr 29;9:633925. doi: 10.3389/fcell.2021.633925

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Copyright © 2021 Koeppert, Ghallab, Peglow, Winkler, Graeber, Büscher, Hengstler and Jahnen-Dechent.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential clearance of free fetuin-A protein, CPM and CPP. Mice were injected with 100 μg (900 μg total protein) CPM-associated Alexa488 (green) or Alexa546-labeled fetuin-A (red). Control mice were injected with Alexa488- and Alexa546-labeled free fetuin-A monomer, or with 100 μg (total protein content) Alexa488/546-labeled CPP-1 and CPP-2. Mice were sacrificed 10 min after injection and counterstained (DAPI, blue) and kidney (A–C) and liver (D,E) frozen sections were analyzed by fluorescence microscopy. CPM were readily detected in kidney (B) and liver (E), while CPP-1 and CPP-2 were detectable in liver (F) but not in kidney (C). Free fetuin-A monomer was not detected in kidney or in liver (A,D). Scale bar: 75 μm.