Table 4.

Consolidated summary of results.

Type of spot		Key In situ findings	Characteristic gene expression level
Red spot	Early	Few M1 macrophages in PRV-1 positive hemorrhages.	Significant upregulation of iNOS2 expression	Significant upregulation of MHC-I and GzmA expression
	Intermediate	High co-localization of PRV-1 in M1 macrophages.
	Late	Detection of few M2 melano-macrophages.
Black spot		Domination of M2 melano-macrophages and co-localization with PRV-1.	Significant upregulation of Arg2 transcription.