TABLE 2.
The adjusted mean differences between groups and 95% confidence intervals for all four FCSRT measures
| FCSRT immediate free recall | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C9orf72 | GRN | MAPT | |||||||||||
| PS | S | PS | S | PS | S | ||||||||
| Controls | –2.9 | –12.5 | 0.4 | –11.7 | –2.4 | –15.7 | |||||||
| –4.1 | –1.7 | –14.8 | –10.2 | –0.8 | 1.6 | –16.3 | –7.1 | –4.0 | –0.7 | –20.8 | –10.6 | ||
| C9orf72 | PS | ‐9.6 | 3.3 | –8.8 | 0.5 | –12.8 | |||||||
| –12.0 | –7.2 | 1.8 | 4.8 | –13.6 | –4.0 | –1.3 | 2.3 | –18.0 | –7.6 | ||||
| S | 12.9 | 0.8 | 10.1 | ‐3.2 | |||||||||
| 10.5 | 15.3 | –4.2 | 5.7 | 7.3 | 12.9 | –8.76 | 2.3 | ||||||
| GRN | PS | –12.1 | –2.8 | –16.1 | |||||||||
| –16.6 | –7.6 | –4.6 | –0.9 | –21.3 | –10.9 | ||||||||
| S | 9.3 | –4.0 | |||||||||||
| 4.7 | 14.0 | –10.4 | 2.5 | ||||||||||
| MAPT | PS | –13.3 | |||||||||||
| –18.4 | –.8.3 | ||||||||||||
| FCSRT immediate total recall | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C9orf72 | GRN | MAPT | |||||||||||
| PS | S | PS | S | PS | S | ||||||||
| Controls | –1.3 | –8.7 | 0.7 | –16.3 | –2.1 | 14.4 | |||||||
| –2.3 | –0.3 | –12.0 | –5.3 | 0.1 | 1.2 | –22.8 | –9.8 | –3.3 | –0.8 | –21.2 | –7.5 | ||
| C9orf72 | PS | –7.4 | 1.9 | –15.0 | –0.8 | –13.1 | |||||||
| –10.8 | –4.0 | 0.8 | 3.1 | –21.7 | –8.4 | –2.2 | 0.7 | –20.0 | –6. 1 | ||||
| S | 9.3 | –7.6 | 6.6 | –5.7 | |||||||||
| 5.9 | 12.7 | –15.2 | –0.1 | 3.0 | 10.2 | –13.6 | 2.2 | ||||||
| GRN | PS | –17.0 | –2.7 | –15.0 | |||||||||
| –23.5 | –10.4 | –4.1 | –1.3 | –21.9 | –8.1 | ||||||||
| S | 14.2 | 1.9 | |||||||||||
| 7.7 | 20.8 | –7.1 | 11.0 | ||||||||||
| MAPT | PS | –12.3 | |||||||||||
| –19.2 | –5.4 | ||||||||||||
| FCSRT delayed free recall | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C9orf72 | GRN | MAPT | |||||||||||
| PS | S | PS | S | PS | S | ||||||||
| Controls | –1.0 | –5.3 | 0.1 | –4.5 | –0.9 | –6.4 | |||||||
| –1.6 | –0.5 | –6.3 | –4.3 | –0.3 | 0.6 | –6.2 | –2.8 | –1.7 | –0.1 | –8.7 | –4.0 | ||
| C9orf72 | PS | –4.3 | 1.1 | –3.5 | 0.1 | –5.4 | |||||||
| –5.4 | –3.2 | 0.5 | 1.8 | –5.3 | –1.7 | –0.8 | 1.0 | –7.8 | –3.0 | ||||
| S | 5.5 | 0.8 | 4.4 | –1.0 | |||||||||
| 4.4 | 6.5 | –1.1 | 2.7 | 3.2 | 5.7 | –3.5 | 1.5 | ||||||
| GRN | PS | –4.6 | –1.0 | –6.5 | |||||||||
| –6.3 | –3.0 | –1.9 | –0.2 | –8.9 | –4.1 | ||||||||
| S | 3.6 | –1.9 | |||||||||||
| 1.8 | 5.4 | –4.7 | 1.0 | ||||||||||
| MAPT | PS | –5.5 | |||||||||||
| –7.8 | –3.2 | ||||||||||||
| FCSRT delayed total recall | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C9orf72 | GRN | MAPT | |||||||||||
| PS | S | PS | S | PS | S | ||||||||
| Controls | –0.3 | –3.1 | 0.1 | –4.3 | –0.7 | –4.5 | |||||||
| –0.6 | 0.0 | –4.4 | –1.9 | –0.1 | 0.4 | –6.7 | –1.9 | –1.3 | –0.2 | –7.1 | –1.9 | ||
| C9orf72 | PS | –2.8 | 0.4 | –4.0 | –0.4 | –4.2 | |||||||
| –4.1 | –1.5 | 0.1 | 0.8 | –6.4 | –1.6 | –1.1 | 0.2 | –6.8 | –1.6 | ||||
| S | –3.3 | –1.2 | 2.4 | –1.4 | |||||||||
| 2.0 | 4.5 | –3.9 | 1.6 | 1.1 | 3.8 | –4.2 | 1.5 | ||||||
| GRN | PS | –4.5 | –0.9 | –4.6 | |||||||||
| –6.8 | –2.1 | –1.5 | –0.3 | –7.2 | –2.1 | ||||||||
| S | 3.6 | –0.2 | |||||||||||
| 1.1 | 6.1 | –3.6 | 3.3 | ||||||||||
| MAPT | PS | –3.8 | |||||||||||
| –6.3 | –1.2 | ||||||||||||
Notes: Values in bold are significant at P < 0.05. Values are adjusted for age, years of education, sex, and language in which the test was administered.
Abbreviations: C9orf72, chromosome 9 open reading frame 72; FCSRT, Free and Cued Selective Reminding Test; GRN, progranulin; MAPT, microtubule‐associated protein tau; PS, presymptomatic; S, symptomatic.