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. 2021 Apr 29;12:664181. doi: 10.3389/fphar.2021.664181

FIGURE 3.

FIGURE 3

Effects of EMPA on left ventricular diastolic function and coronary flow reserve in SNT-treated mice. (A) Representative recordings of mitral valve inflow by pulsed wave Doppler in an apical four-chamber view at the study endpoint among different groups, n = 8 or 12 per group. (B) Left ventricular diastolic function parameters evaluated from mitral valve flow spectrum among different groups, n = 8 or 12 per group. (C) Representative ultrasound tracings of dilated (induced with 2.5% isoflurane) and basal (with 1% isoflurane) coronary flow at the study endpoint. (D) Quantification of coronary flow reserve (dilated/basal flow) among different groups, n = 8 or 12 per group. *p < 0.05 vs. Control, #p < 0.05 vs. SNT.