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. 2021 Apr 29;12:664181. doi: 10.3389/fphar.2021.664181

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Copyright © 2021 Ren, Sun, Zhang, Hu, Hu, Zhao, He, Ding, Wang and Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EMPA ameliorated SNT-triggered cardiomyocyte death and cell viability loss. (A) Representative images of TUNEL positive cells in mice hearts at the study endpoint among different groups and (C) statistical analysis, n = 6 per group, bar = 50 μm. (B) Representative images of Hoechst 33,258 staining in H9c2 cells with different treatments and (D) statistical analysis, n = 6 per group, bar = 50 μm. (E) CCK-8 viability assay of H9c2 cardiomyocytes treated with vehicle or different concentrations of SNT (ranging from 1 to 20 μM), n = 6 per group. (F) CCK-8 viability assay of H9c2 cardiomyocytes treated by vehicle, SNT (5 μM), or SNT plus EMPA (ranging from 50 to 1,000 nM), n = 6 per group. *p < 0.05 vs. control, #p < 0.05 vs. SNT.