TABLE 1.

Role of HSP in pregnancy.

HSP class	Role in pregnancy	References
HSP27	Facilitate decidualization	Ciocca et al., 1996
	Promote pathogenesis of pre-eclampsia	Shin et al., 2011
HSP40	Impair pre-term delivery related mechanism	Makri et al., 2019
	Promote pathogenesis of pre-eclampsia	Yang et al., 2015
HSP60	Induce synthesis of steroid hormones, particularly progesterone synthesis	Olvera-Sanchez et al., 2019
	Promote blastocyst development	Esfandiari et al., 2002
HSP70	Maintain of integrity of decidual cells	Tan et al., 2007
	Induce “Proinflammatory Maturation Program” in decidual dendritic cells	Redzovic et al., 2015
	Promote blastocyst development	Esfandiari et al., 2002
	Protect embryos from the lethal effects of hyperthermia	Mirkes et al., 1999
HSC70	Modulate receptivity of decidualizing hESCs	Brosens et al., 2014
	Promote decidualization
	Induce of endoplasmic reticulum (ER) stress in the hESCs
GRP78	Promote syncytialisation	Fradet et al., 2012
	Cope endoplasmic reticulum stress	Brosens et al., 2014
	Facilitate syncytialisation	Fradet et al., 2012
HSP90	Promote steroid receptor maturation and recognition of steroid receptors	Kimmins and MacRae, 2000
HSP105	Favor embryo implantation	Yuan et al., 2009