TABLE 10.
Effect of piperine on the pharmacokinetic parameters of the marker compounds viz, diosgenin, charantin, and hydroxychalcone after administration of the herbal formulations.
| Parameters | Diosgenin | Charantin | Hydroxychalcone | |||
|---|---|---|---|---|---|---|
| F1 (75 mg/kg per oral) (µg/ml) | F2 (75 mg/kg per oral) µg/ml) | F1 (75 mg/kg per oral) (µg/ml) | F2 (75 mg/kg per oral) (µg/ml) | F1 (75 mg/kg per oral) (µg/ml) | F2 (75 mg/kg per oral) (µg/ml) | |
| Kel (h−1) | 0.0900 ± 0.004 | 0.0890 ± 0.001 | 0.0896 ± 0.0003 | 0.0844 ± 0.003 | 0.1450 ± 0.002 | 0.1412 ± 0.005 |
| t 1/2 (h) | 7.7088 ± 0.32 | 7.7838 ± 0.117 | 7.7316 ± 0.025 | 8.2130 ± 0.25 | 4.7801 ± 0.08 | 4.9129 ± 0.169 |
| Cl (mg/h/kg) | 0.3456 ± 0.02 | 0.2199 ± 0.004 | 0.5553 ± 0.006 | 0.4548 ± 0.02 | 0.0685 ± 0.001 | 0.0350 ± 0.001 |
| AUC 0 ∞ (µg.h/ml) | 1.9838 ± 0.02 | 2.7006 ± 0.006 | 1.6009 ± 0.034 | 2.3419 ± 0.05 | 1.4294 ± 0.01 | 1.6772 ± 0.003 |
| Cmax (µg/ml) | 0.1962 ± 0.002 | 0.2975 ± 0.002 | 0.1008 ± 0.002 | 0.1506 ± 0.002 | 0.0954 ± 0.002 | 0.1517 ± 0.0001 |
| Tmax (h) | 1 | 1 | 6 | 6 | 1 | 1 |
| AUMC0 ∞ | 19.7230 ± 0.25 | 26.1961 ± 0.40 | 21.3542 ± 0.54 | 33.7730 ± 1.58 | 12.490 ± 0.20 | 12.7395 ± 0.27 |
| MRT (h) | 9.9420 ± 0.03 | 9.700 ± 0.15 | 13.3383 ± 0.05 | 14.4165 ± 0.38 | 8.7378 ± 0.08 | 7.5954 ± 0.15 |
| Ka (h−1) | 1.0 ± 0.02 | 1.1 ± 0.03 | 0.73 ± 0.04 | 0.41 ± 0.04 | 1.2 ± 0.09 | 1.5 ± 0.24 |
Results are presented as mean ± SD (n = 6), (Kel-Elimination rate constant, t1/2- plasma half-life, Cl-drug clearance, AUC- area under curve, Cmax-maximum concentration of the drug, Tmax-the time taken by a substance to reach the Cmax, AUMC- A under the moment curve, MRT-mean residence time, and Ka-rate of absorption).