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. 2021 Apr 29;9:642212. doi: 10.3389/fcell.2021.642212

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Copyright © 2021 Iakovlev, Faravelli and Becskei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of dichotomization methods. (A) The histogram of the Pcdhac2 transcript numbers in the somatosensory neurons. The dichotomization yielded the following thresholds: 2.11 (GTME), 6.28 (FM), and 20.21 (VRS) TPM. The fitted probability density function (pdf) is a mixture of normal distributions, with an antimode at 1.37. The pdf is integrated piecewise according to the logarithmic bins. The thumbnail plot is a version of the main plot with a linearly scaled x-axis. (B) Pair-wise scatter plots showing the ON cell frequencies of each gene in the somatosensory neuron dataset with a bimodality coefficient greater than 0.55, after dichotomization with different methods. (C) The Spearman rank correlation of the ON cell frequencies shown in (B).