Fig. 2.

Cpsn or TX100 increases the CD’s ion pore induction potency. TCC (90 μM) alone permeabilizes lipid bilayer membranes by inducing nonzero current events (top panel). Middle and bottom panels represent the TCC induced current events being influenced by the effects of 90 μM Cpsn and 30 μM TX100, respectively, added into the aqueous phases in both chambers. Both traces were filtered at 20 kHz. The buffer in the cuvette was 500 mM NaCl containing 90 μM TCC at the cis side of the membrane and 0 μM TCC at the trans side of the membrane; 100 mV, pH 7.4.