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. 2021 Apr 29;12:647650. doi: 10.3389/fphar.2021.647650

FIGURE 1.

FIGURE 1

lncRNA MALAT1 was upregulated in STZ-induced diabetic rats and HG-treated HK-2 or 293T cells. (A) Expression of the MALAT1 level was detected by RT-qPCR in STZ-induced diabetic rats (n = 10) and control rats (n = 10). HK-2 cells were treated with NG, mannitol, and HG for 24, 48, and 72 h, respectively. (B and C) Effects of different treatments on cell proliferation and invasion of HK-2 cells at 0, 24, 48, and 72 h were detected by CCK-8 and Transwell assays. *p < 0.05 vs. NG or mannitol group, **p < 0.01 vs. NG or mannitol group. (D and E) Effects of different treatments on the expression of col I, col IV, FN, and LN in HK-2 cells were detected by densitometric analysis. *p < 0.05 or **p < 0.01 vs. NG group or mannitol group. (F and G) lncRNA MALAT1 expression was detected by RT-qPCR in HK-2 or 293T cells. *p < 0.05 or **p < 0.01 vs. NG or mannitol group.