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. 2021 Apr 29;15:636144. doi: 10.3389/fnhum.2021.636144

FIGURE 1.

FIGURE 1

Flow chart for timeline of the current non-human primate study. A flow chart is provided depicting the two phases of the study. In the left-hand panel (in gray) is the infancy stage, during which the early life stress exposure occurs—the maternal variable foraging demand (VFD) paradigm (red arrow)—or the control condition—the non-VFD group (yellow arrow) where VFD is not imposed. In the right-hand panel side (in green) is the adult phase of the study. The baseline period comprises 12 weeks of blinded behavioral observations (blue arrows), whereas in the ensuing 12-week period, a portion of both groups are exposed to the repeated separation paradigm (RSP) (light green) or to no-RSP (light red). The number of subjects at each phase is shown in the diagram. The first cerebrospinal fluid (CSF) sample was obtained following the baseline observation period, whereas the second CSF was obtained following the RSP period (yellow arrows at bottom). Abbreviations: VFD, variable foraging demand; RSP, repeated separation paradigm; CSF, cerebrospinal fluid.