FIGURE 5.

CSF log kynurenic acid/kynurenine ratio correlation with social affiliation observed during repeated separation paradigm as a function of the variable foraging demand form of early life stress. Only in VFD was there a positive relationship between social affiliation cores and the neuroprotective index represented by CSF KYNA/KYN. The positive relationship was in the expected direction. For any increment in VFD CSF log KYNA/KYN, there was a commensurate increase in social affiliation. Of note, this was the affiliation behavioral scores of the second of the five 2-week behavioral blocks (see RESULTS for further information). Abbreviations: VFD, variable foraging demand; KYNA, kynurenic acid; KYN, kynurenine; CSF, cerebrospinal fluid.