Table 4.
IC50 values in A2780 (ovarian) and A2780CP70 (ovarian cisplatin-resistant) cells in the absence and presence of 365 nm light.
| Compound | IC50 Value (μM) | |||||
|---|---|---|---|---|---|---|
| A2780 |
PI | A2780CP70 |
PIa | |||
| Dark | Light | Dark | Light | |||
| THP-1 | >200 | 4.6 ± 1.4 | 43.5 | >200 | 29.9 ± 7.7 | 6.7 |
| DAPTA-1 | >200 | 2.2 ± 1.1 | 90.9 | >200 | 3.2 ± 0.7 | 62.5 |
| Cisplatin | 0.18 ± 0.07 | – | – | 5.14 ± 1.1 | – | – |
a
Phototoxic index (PI) is the dark IC50 value divided by the light IC50 value. For light-irradiated samples, an irradiation time 1 h with 365 nm light at a photon flux (2.38 ± 0.31) × 10−10 Einsteins/s was employed.