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. 2021 Apr 29;11:657546. doi: 10.3389/fonc.2021.657546

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Copyright © 2021 Liu, Luo, Huang, Chen and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epigenetic Regulators of EMT and MET. Epigenetic modulators involved in histone modification, DNA methylation, and non-coding RNA in EMT/MET that regulate cancer metastasis are depicted. Epigenetic regulators can either be recruited by EMT-TFs to regulate the expression of downstream EMT-associated genes, or they can directly function as either transcriptional suppressor or activators of EMT-TFs as well as downstream EMT-associated genes.