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. 2021 May 11;218(7):e20202477. doi: 10.1084/jem.20202477

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© 2021 Nguyen et al.

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Figure S5. — Loss of Cbl-b in W131AOTII mice altered gene expression profile. (A) Principal component analysis with principal component 1 (PC1) and PC3 of CD25⁻Vα2⁺ peripheral naive CD4 T cells from the indicated mouse strains (n = 3–12 mice/group). (B) Expression of genes that belong to gene ontology: 0002376–immune system process pathway in peripheral naive CD25⁻Vα2⁺CD4⁺ T cells from Cbl-b^−/−W131AOTII mice was compared with those cells from W131AOTII mice. (C) Volcano plot revealed expression of anergy-associated genes, T reg cell–associated genes, inhibitory genes influencing cytokines and TCR signaling, and exhaustion genes in peripheral naive CD25⁻Vα2⁺CD4⁺ T cells from Cbl-b^−/−W131AOTII mice compared with those cells from W131AOTII mice. NA, not applicable.