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. 2021 Apr 29;11:583547. doi: 10.3389/fonc.2021.583547

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Copyright © 2021 Shi, Bi, Yu, Wang, Teng and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification, construction, and validation of the TII prognostic model system in CRC. (A, B) Patient survival data in the two risk groups. (C) Heatmap plot showing differences in levels of identified hub immune signature between high-risk and low-risk groups. (D) Kaplan-Meier curves of prognostic signature for CRC patients. (E) 3-year ROC curves for prognostic predictors. Univariate (F) and multivariate (G) Cox regression analyses were conducted to assess the immune-related signatures and clinic characteristics using Forest plots.