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. 2021 Apr 29;12:649921. doi: 10.3389/fphys.2021.649921

FIGURE 4.

FIGURE 4

Acute inhibition of aldosterone signaling lowers circulating FGF23 in mice with CKD. Serum levels of circulating intact FGF23 before and 24 h (A) or 72 h (B) after a single iv injection (A) or two sc injections at 0 and 48 h (B) of the mineralocorticoid receptor antagonist canrenone to mice with established CKD, 12 weeks after 5/6-Nx (n = 4–6 each). *P < 0.05 by Wilcoxon test.