Table 1:

Role of resistin in different cancers

Type of cancer	Effect	Mechanism of action	References
Breast	Invasion and Migration	Calcium-dependent c-Src and PKCα-ezrin pathway	[102]
	Metastasis	Induction of EMT and stemness	[120]
	Doxorubicin-resistance	AMPK/mTOR/ULK1 and JNK signaling pathways	[137]
	Chemoresistance and stemness	STAT 3 pathway	[40]
	Progression	Induction of EMT and stemness by TLR4/NF-κB/S TAT3 signaling pathway	[19]
Colorectal	CRC stage progression	Higher levels of resistin	[138]
	G1 arrest of cells	ERK/ SOCS3/ JAK2/STAT3 pathway	[88]
	Inhibition to apoptosis by 5-fluorouracil	G1 arrest of cells	[88]
	Endothelial adhesion	NF-κβ pathway and expression of ICAM-1A and VCAM-1	[104]
Myeloma	Multidrug resistance	NF-κB and PI3K/Akt pathways and ABC transporter	[97]
Ovarian	Angiogenesis	PI3K/Akt-Sp1 pathway and VEGF expression	[124]
	Invasion and Cisplatin-resistance	Induction of EMT and stemness by tumor suppressor miRNAs, let-7a, miR-200c, and miR-186	[89]
Gastric	SDF-1 expression	p38 MAPK and NF-κβ pathway	[139]
Prostate	Cell proliferation	PI3K/Akt signaling pathways	[91]
Liver	Adhesion to human umbilical vein endothelial cells (HUVECs)	NF-κB-regulated ICAM-1 and VCAM-1 expression	[103]
Pancreatic	Proliferation, migration, invasion and gemcitabine resistance	STAT3 signaling pathway	[20]
Lung	Development and metastasis	Expression of Wolf-Hirschhorn syndrome candidate 1 (WHSC1) histone methyltransferase and TWIST	[53]
	Invasion and metastasis	TLR4/Src/EGFR/PI3K/NF-κβ pathway	[101]