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. 2021 May 12;12:284. doi: 10.1186/s13287-021-02359-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Cell proliferation and invasion before and after malignant transformation. Cell proliferation was significantly faster in the MTMSC, MTMSC-PEG3-FTH1, and MTMSC-CMV-FTH1 groups than in the MSC, MSC-PEG3-FTH1, and MSC-CMV-FTH1 groups, respectively, beginning on the 3rd day after the cells were seeded (a). The number of cells that migrated though the membrane was notably larger in the MTMSC, MTMSC-PEG3-FTH1, and MTMSC-CMV-FTH1 groups than in the MSC, MSC-PEG3-FTH1, and MSC-CMV-FTH1 groups, respectively (b). There were significant differences in the cell invasion ratio between the corresponding pre- and post-malignant transformation groups (c)