TABLE 2.
Dexketoprofen pharmacokinetic parameters based on sex and race.
| N | AUC/DW (kg*h*ng/mL*mg) | SD | Cmax/DW (kg*ng/mL*mg) | SD | Tmax (h) | SD | T1/2 (h) | SD | Vd/F (ml/kg) | SD | Cl/F (mL/h*kg) | SD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex | Male | 43 | 11,253.32 | 2,233.52 | 7,328.16 | 1,467.24 | 0.62 | 0.31 | 2.27 | 0.35 | 297.69 | 47.36 | 92.36 | 17.10 |
| Female | 42 | 10,032.45* | 1822.22 | 7,122.11 | 1730.30 | 0.76 | 0.53 | 2.25 | 0.37 | 331.29* | 59.57 | 103.20* | 18.42 | |
| Race | Caucasian | 70 | 10,776.95 | 2097.40 | 7,210.42 | 1,567.78 | 0.71 | 0.46 | 2.30 | 0.37 | 315.75 | 58.72 | 96.52 | 18.67 |
| Latin—american | 13 | 9,481.61 # | 1,209.83 | 7,053.52 | 1732.39 | 0.62 | 0.33 | 2.02 # | 0.19 | 310.28 | 32.70 | 107.26 # | 12.82 | |
| Black | 1 | 10,849.29 | — | 7,810.99 | — | 0.50 | — | 2.70 | — | 364.42 | — | 94.13 | — | |
| Asian | 1 | 16,758.60 | — | 10,003.27 | — | 0.42 | — | 2.46 | — | 214.20 | — | 60.59 | — | |
SD: standard deviation; *: after T-test comparing men with women; #: p < 0.05 after T-test comparing Caucasian with Latin-American (Black and Asian were not included in this analysis because of the low number of subjects).; Underlined: p < 0.05 after multivariate analysis (linear regression, which included the following variables: sex, race, CYP2B6 phenotype, CYP2D6 phenotype, CYP1A2*1B, ABCB1 C3435T (rs1045642), G2677 T/A (rs2032582), and C1236T (rs1128503)).
The bold values simply serve to highlight significant results.