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. 2021 Apr 12;12:640032. doi: 10.3389/fphar.2021.640032
GRADE LOW There is some evidence that pharmacogenetic-guided treatment with antidepressants results in a higher chance of remission of depression and better treatment response than standard care.
Pharmacogenetic-guided treatment was formulated based on results of CYP1A2, CYP2C19 and CYP2D6. Pharmacodynamic genes were also determined but are outside the scope of this guideline.
Sources: Hall-Flavin et al. (2012); Hall-Flavin et al. (2013); Singh (2015); Winner et al. (2013); Perez et al. (2017); Bradley et al. (2018); Greden et al. (2019)
-GRADE No studies were found investigating the effect of pharmacogenetic-guided treatment compared to standard care in psychiatric patients using antipsychotics.
-GRADE No studies were found investigating the effect of pharmacogenetic-guided treatment compared to standard care on side effects in psychiatric patients using antidepressants.