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. 2021 Apr 29;12:675678. doi: 10.3389/fimmu.2021.675678

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Copyright © 2021 Della-Torre, Lanzillotta, Campochiaro, Cavalli, De Luca, Tomelleri, Boffini, De Lorenzo, Ruggeri, Rovere-Querini, Castagna, Landoni, Tresoldi, Ciceri, Zangrillo and Dagna

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Cumulative incidence of long-term survival of patients treated with biologic drugs compared to patients treated with standard of care (PaO2/FiO2 ratio < mmHg). Kaplan-Meier curves showing the cumulative incidence of overall survival up to 186 days of patients presenting with a PaO2/FiO2 ratio < mmHg and treated with biologic drugs (A), anakinra (B), sarilumab (C), and tocilizumab (D), compared to standard of care. Time to death is expressed in days from the day of enrolment. A, anakinra; B, biologic drugs; C, comparators treated with standard of care; S, sarilumab; T, tocilizumab; HR, hazard ratio; CI, confidence interval. Statistically significant p value < 0.05.