Table 7.
Clinical and serological features of patients with a PaO2/FiO2 ratio < 100 mmHg and ≥ 100 mmHg.
| PaO2/FiO2 ratio ≥ 100 mmHg | PaO2/FiO2 ratio < 100 mmHg | |||||
|---|---|---|---|---|---|---|
| Biologics (n=42) | Standard of care (n=59) | p value | Biologics (n=65) | Standard of care (n=44) | p value | |
| Age (years) | 58 (51-68.25) | 61 (55-71) | 0.46 | 62 (55.5-73.5) | 63 (58-73) | 0.27 |
| Male sex, n (%) | 31 (74%) | 38 (64%) | 0.51 | 36 (55%) | 19 (43%) | 0.22 |
| Comorbidities | ||||||
| HBP | 12 (29%) | 22 (37%) | 0.39 | 27 (42%) | 23 (52%) | 0.33 |
| CAD | 1 (2%) | 10 (17%) | 0.03 | 10 (15%) | 8 (18%) | 0.99 |
| Type 2 diabetes | 3 (7%) | 10 (17%) | 0.23 | 14 (22%) | 11 (25%) | 0.65 |
| COPD | 0 (0%) | 3 (5%) | 0.25 | 4 (6%) | 4 (9%) | 0.71 |
| Cancer | 2 (5%) | 7 (12%) | 0.3 | 3 (5%) | 1 (2%) | 0.65 |
| CRF | 0 (0%) | 3 (5%) | 0.26 | 7 (11%) | 4 (9%) | 0.99 |
| PaO2/FiO2 ratio (mmHg) | 144 (119-185) | 172 (127-229) | 0.1 | 77 (67-87) | 73 (61-86) | 0.59 |
| Laboratory values | ||||||
| LAD (125-220 IU/L) | 432 (350-547) | 415 (377-540) | 0.71 | 487 (407-595) | 565 (436-726) | 0.07 |
| CRP (< 6 mg/L) | 134 (97-172) | 153 (123-192) | 0.07 | 166 (122-239) | 202 (135-238) | 0.41 |
| Ferritin (30-400 ng/mL) | 1422 (1054-2835) | 2326 (1254-3215) | 0.18 | 1731 (938-3099) | 1717 (1198-3871) | 0.28 |
| IL-6 (< 7 pg/mL) | 56 (37-113) | 51 (26-116) | 0.49 | 58 (37-120) | 105 (66-286) | 0.08 |
Results are reported as median (interquartile range) unless specified; statistically significant p value < 0.05. HBP, high blood pressure; CAD, coronary artery disease; COPD, chronic obstructive pulmonary disease; CRF, chronic renal failure; LAD, lactate dehydrogenase; CRP, C-reactive protein; IL-6, interleukin-6.
Bold values indicate that the p values are statistically significant.