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. 2021 Apr 28;12:600618. doi: 10.3389/fphar.2021.600618

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Copyright © 2021 Huang, Zhang, Wang and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of the possible mechanisms of PPARγ in the organ IRI. The mechanism includes different effects of different PPARγ agonists. NMDA, N-methyl-D-aspartic acid; eNOS, endothelial NO synthase; iNOS, inducible NO synthase; Nrf2, nuclear factor-erythroid 2-related factor 2; RAGE, receptor for advanced glycation end products; SIRT6P, the endogenous retinoid X receptor and sirtuin 6; Fox03a; BBB, blood–brain barrier; MMB, matrix metalloproteinase; TIMPs, tissue inhibitor of metalloproteinase; TXNIP, thioredoxin interacting protein; NLRP3, nod-like receptor family, pyrin domain containing 3; SCP2, sterol carrier protein 2; ACADI, long-chain acyl CoA dehydrogenase; UCP2, mitochondrial uncoupling protein 2.