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. 2021 Apr 29;12:630419. doi: 10.3389/fphar.2021.630419

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Copyright © 2021 Franzin, Stasi, Ranieri, Netti, Cantaluppi, Gesualdo, Stallone and Castellano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Senolytic agents in transplantation field. The administration of senolytic agents in donor (left), in normothermic-perfusion device (middle), and in recipient (right) is considered a therapeutic approach to improve the quality of older donor organs that have traditionally been considered unusable for transplantation. Adapted from Lau A, Kennedy BK, Kirkland JL, Tullius SG. Mixing old and young: enhancing rejuvenation and accelerating aging. J Clin Invest. 2019 Jan 2; 129 (1), 4–11.