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. 2021 May 13;12:288. doi: 10.1186/s13287-021-02368-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — ADM2 accelerated bone consolidation during distraction osteogenesis in diabetic rats. A Mechanical tests (E-modulus, ultimate load, and energy to failure) of the distracted tibias. The values were normalized to the corresponding contralateral normal tibias. B Representative X-rays of distraction regenerate at various time points of the consolidation phase in the four groups. C Representative 3D and longitudinal images of the tibial distraction zone after 2 and 4 weeks of consolidation and treatment. D Quantitative analysis of bone mineral density (BMD) and bone volume/tissue volume (BV/TV) of the regenerated bone. The data were confirmed by one-way analysis of variance (ANOVA) followed by Tukey’s post hoc test from three independently repeated tests and are presented as the means ± SD. *P < 0.05; **P < 0.01