Table 3.
Effect of CPAP therapy − per-protocol analysis
| Characteristic | Baseline | Mean change (95% CI) 3 months-BL | p value | Mean change (95% CI) 12 months-BL | p value | Mean change (95% CI) 24 months-BL | p value |
|---|---|---|---|---|---|---|---|
| AHI events/h | 51.9±14.4 | −45.3 (−48.0; −42.6) | <0.001 | −46.1 (−48.9; −43.4) | <0.001 | −46.9 (−49.8; −44.1) | <0.001 |
| ODI >3% − events/h | 46.4±14.4 | −38.4 (−41.0; −35.9) | <0.001 | −39.4 (−42.0; −36.8) | <0.001 | −39.6 (−42.3; −36.9) | <0.001 |
| Score on Epworth sleepiness scale | 13.4±3.6 | −5.5 (−6.0; −5.0) | <0.001 | −5.9 (−6.4; −5.4) | <0.001 | −6.2 (−6.7; −5.7) | <0.001 |
| SF-36 vitality score | 43±14 | 20 (18; 23) | <0.001 | 21 (19; 24) | <0.001 | 19 (17; 22) | <0.001 |
| EQ-5D utility index | 0.79±0.16 | 0.01 (−0.01; 0.03) | 0.516 | 0.01 (−0.01; 0.03) | 0.412 | 0.02 (0.00; 0.04) | 0.056 |
| EQ-5D utility index, adjusteda | 0.01 (−0.01; 0.03) | 0.529 | 0.01 (−0.01; 0.03) | 0.547 | 0.02 (0.00; 0.04) | 0.064 | |
| SF-6D utility index | 0.72±0.13 | 0.05 (0.03; 0.06) | <0.001 | 0.05 (0.04; 0.07) | <0.001 | 0.06 (0.04; 0.07) | <0.001 |
| SF-6D utility index, adjusteda | 0.05 (0.03; 0.06) | <0.001 | 0.05 (0.04; 0.07) | <0.001 | 0.06 (0.04; 0.07) | <0.001 | |
| Euro-thermometer VAS utility index | 0.70±0.16 | 0.08 (0.06; 0.11) | <0.001 | 0.09 (0.07; 0.11) | <0.001 | 0.09 (0.07; 0.11) | <0.001 |
| Euro-thermometer VAS utility index, adjusteda | 0.08 (0.06; 0.11) | <0.001 | 0.09 (0.07; 0.11) | <0.001 | 0.09 (0.07; 0.12) | <0.001 | |
| SG utility index | 0.82±0.18 | 0.01 (−0.01; 0.03) | 0.273 | 0.02 (0.00; 0.04) | 0.080 | −0.01 (−0.03; 0.01) | 0.407 |
| Standard gamble utility index, adjusteda | 0.01 (−0.01; 0.04) | 0.187 | 0.02 (0.00; 0.05) | 0.034 | −0.01 (−0.03; 0.02) | 0.638 | |
| TTO utility index | 0.82±0.17 | 0.04 (0.02; 0.07) | 0.001 | 0.05 (0.02; 0.07) | <0.001 | 0.04 (0.02; 0.07) | 0.002 |
| TTO utility index, adjusteda | 0.04 (0.02; 0.06) | <0.001 | 0.04 (0.02; 0.07) | <0.001 | 0.04 (0.02; 0.06) | <0.001 |
ODI, oxygen desaturation index >3% dips; SF-36, short-form medical outcome questionnaire; EQ-5D, EuroQol 5-dimensions questionnaire; SF-6D, short-form 6 dimension; VAS, visual analog scale; BL, baseline; CPAP, continuous positive airway pressure; AHI, apnea-hypopnea index; TTO, time trade-off; SG, standard gamble.
a
Adjusted for baseline values of the corresponding variable.