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. Author manuscript; available in PMC: 2021 May 13.
Published in final edited form as: Acc Chem Res. 2019 Nov 13;52(12):3407–3418. doi: 10.1021/acs.accounts.9b00377

Figure 2.

Figure 2.

(A) Titration of dual 3FY/4FF-labeled KIX with MLL; perturbed residues are highlighted in yellow in (B) (PDB: 2AGH). (C) PrOF NMR screening identifies a fragment interaction near Y631. Adapted with permission from ref 44. Copyright 2018 John Wiley & Sons. (D) Ligands characterized using 3FY-KIX.