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PrOF NMR titrations of (+)-JQ1 in BRD4-D1 labeled with (A) 5FW and (B) 3FY. (C) Screening of kinase inhibitors against mixtures of 5FW-BRD4-D1 and 5FW-BPTF (adapted with permission from refs 23 and 60. Copyright 2014 and 2015 American Chemical Society, respectively). (D) Bromodomain inhibitors and fragments characterized by PrOF NMR.23,61-63
